TBTU (CAS 125700-67-6)

TBTU (CAS 125700-67-6) About

TBTU, chemically known as 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate, is a highly efficient organic salt widely utilized as a standard chemical reagent in organic synthesis. It is a critical component in both solid-phase and solution-phase peptide synthesis, designed to facilitate fast, clean condensation between carboxylic acids and amines.

TBTU (CAS 125700-67-6) possesses the molecular formula CHBFNO and a molecular weight of 321.08 g/mol. Structurally, although it has historically been named and depicted as a uronium salt, it actually exists predominantly in its aminium (N-oxide) crystalline form. The compound features a benzotriazole moiety that balances reactivity and stability, paired with a non-nucleophilic tetrafluoroborate (\(BF_{4}{-}\)) counterion that ensures excellent solubility properties in polar aprotic solvents